Coronary artery disease—from bench to bedside

Coronary microembolization: from bedside to bench and back to bedside.

Coronary microembolization from the erosion or rupture of a vulnerable atherosclerotic plaque occurs spontaneously in acute coronary syndromes and iatrogenically during percutaneous coronary interventions. Typical consequences of coronary microembolization are microinfarcts with an inflammatory response, contractile dysfunction, and reduced coronary reserve. Apart from transient elevations of c...

From bench to bedside

Because the microcirculation has emerged as an important reanimation target, appropriate methods to monitor the microcirculatory function are crucial. Several teams have now succeeded in crossing this bridge from bench to bedside, but the choice of the tissues of interest remains a debate. The potential accessible vascular beds that doctors could use in reanimation strategies and the relationsh...

Bench to bedside review

From Bench to Bedside

Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene trans...

Asthma: bench to bedside

P108 Table Variable Asthmatic (n = 34) Mean (95% CI) Inflammatory (n = 20) Mean (95% CI) Non-inflammatory (n = 18) Mean (95% CI) Overall ANOVA Age (years) 49.9 (43.6 to 56.1) 54.1 (45.9 to 62.2) 50.2 (45.7 to 54.6) 0.577 Duration rhinitis (years) 15.9 (11.5 to 20.4) 14.3 (6.3 to 22.3) 17.7 (10.3 to 25.0) 0.773 Exhaled NO (ppb)* 34.3 (25.9 to 45.3) 48.2 (36.0 to 64.5) 15.4 (11.1 to 21.3) ,0.005 ...